Newest by Mastelli polynucleotide treatment in Maidenhead

Clinical overview

Newest by Mastelli delivers highly purified polynucleotides (PN) into the skin to activate fibroblast proliferation, stimulate collagen and elastin synthesis, and restore hydration at a cellular level. The formulation is designed to support genuine tissue regeneration and bio-revitalisation rather than simply adding volume or attracting water. We use Newest selectively for patients showing signs of skin ageing, dehydration, fine lines, loss of elasticity and dullness across a range of areas including the face, neck, décolletage and hands. The treatment is particularly well suited to patients seeking gradual, natural-looking improvement in skin quality. Suitability is confirmed during consultation, where we assess your skin quality, medical history, expectations and whether Newest (or an alternative polynucleotide or regenerative treatment) is the most appropriate choice for your goals.

Key Benefits

These are the main clinical and practical reasons patients choose Newest by Mastelli polynucleotide treatment in Maidenhead. Your treatment plan is tailored after consultation rather than selected from a fixed package.

• Stimulates tissue repair and regeneration at a cellular level through polynucleotide activity
• Improves skin hydration, elasticity and firmness through collagen and elastin synthesis
• Bio-revitalising formulation by Mastelli, a specialist in regenerative injectable treatments
• Suitable for face, neck, décolletage and hands
• Minimal downtime for most patients

Suitable For

Suitability depends on your goals, skin or tissue characteristics, medical history, and tolerance for downtime. These criteria are reviewed in detail during your assessment.

• Fine lines, crepey skin or loss of elasticity on face, neck, décolletage or hands
• Dehydrated, dull or tired-looking skin where regeneration is the priority
• Patients who want to improve skin quality through tissue repair rather than volume
• Those seeking gradual, natural-looking improvement in skin tone and texture
• Patients comfortable with a course of treatment for cumulative results

Not Suitable For

Some patients should avoid or defer treatment for safety reasons. We screen carefully before any procedure and explain alternatives where relevant.

• Active infection or inflammation in the treatment area (treatment should be delayed)
• Pregnancy or breastfeeding
• Known allergy to fish-derived products (Newest contains polynucleotides derived from fish DNA)
• Patients seeking volume restoration or structural contouring (a different plan is usually more appropriate)
• Anyone with unrealistic expectations of immediate or dramatic transformation

Final suitability is confirmed during a medical consultation and assessment.

When we don't recommend it

A consultation may identify scenarios where a different treatment route is safer or more effective for your outcome goals.

• If volume loss is the primary concern — Newest improves skin quality and hydration but does not replace lost volume. We may recommend dermal fillers or an alternative approach.
• If you have a known fish allergy — Newest contains polynucleotides derived from fish DNA and is not suitable for patients with fish-derived product allergies.
• If there is active inflammation or infection in the treatment area — we will delay treatment until your skin has settled.
• If expectations are for immediate visible change — Newest works gradually over a course of sessions and we will set realistic expectations during consultation.
• If another regenerative treatment or combination would deliver a safer or more effective result for your specific skin concerns.

What Happens During Treatment

We follow a consultation-first process with clear consent and aftercare. You can also review our full consultation standards.

1. 1Clinical consultation and suitability assessment, including medical history, skin assessment and your goals
2. 2Discussion of expected outcomes, limitations, risks and alternatives (including when we may recommend something else)
3. 3Treatment planning and consent, with aftercare guidance tailored to your skin and lifestyle
4. 4Newest is injected using fine needles into the targeted areas (face, neck, décolletage or hands)
5. 5Post-treatment checks and clear instructions on what is normal, and when to contact us

Downtime & Aftercare

Recovery guidance helps protect your result and reduce avoidable complications. We provide written aftercare and safety-net advice at every appointment.

• Slight redness, swelling or tenderness at injection sites is common and usually settles within 24–48 hours
• Small injection-point bumps may be visible temporarily
• Avoid heavy exercise, saunas/steam rooms and alcohol for 24 hours
• Avoid touching or massaging the treated area on the day of treatment unless instructed
• If you have unexpected or worsening symptoms, contact the clinic for advice

Results Timeline

Most treatments improve in stages rather than immediately. Timelines vary by treatment type, treatment area, and individual response.

• A typical course involves 3–4 sessions, spaced 3–4 weeks apart (your plan may differ based on assessment).
• Improvement is gradual and cumulative — skin quality, hydration and texture develop over the course of treatment.
• We review outcomes and discuss whether maintenance or complementary treatments would support your goals.

Individual results vary. View our results and photography standards

Risks & Side Effects

Every medical treatment carries potential risks. We discuss these in plain language before treatment so you can make an informed decision.

Common, Usually Temporary

• •Slight redness, swelling or tenderness at injection sites (usually settles within 24–48 hours)
• •Small injection-point bumps that resolve quickly
• •Bruising (risk varies by individual and medications/supplements)

Frequently Asked Questions

These answers cover common practical questions. If you need individual advice, please book a medical consultation.