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Plinest Polynucleotides: A Complete Guide

A doctor-led patient guide to Mastelli Plinest polynucleotide skin regeneration

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Clinically reviewed by , Medical Director, MBBSGMC 6159259

Plinest is one of the two main polynucleotide injectables used in the UK (alongside Ameela). Manufactured by Mastelli in Italy, Plinest uses the company’s patented PN-HPT technology to produce long-chain purified polynucleotides that stimulate the skin’s regenerative response — improving texture, hydration, elasticity and overall quality.

This guide explains what Plinest is, what PN-HPT technology means in practice, what Plinest treats, how it compares to Ameela and Profhilo, and how we use it at Berkshire Aesthetics in Maidenhead. It is reviewed by Dr Selena Langdon, Medical Director (GMC 6159259).

Plinest at a glance

Typical cost (UK)
From £425 per session; course of 2–3 £850–£1,275
Sessions
2–3 sessions, 3–4 weeks apart; maintenance every 6–9 months
Appointment time
20–30 minutes
Downtime
Small bumps settle in 24 hours; possible mild bruising
Results visible
Skin quality improvement at 4–8 weeks; peak at 2–3 months
Results last
6–9 months after a full course
Best for
Fine lines, dehydrated skin, crepey under-eye, post-acne texture, early laxity, neck and décolletage
Not suitable if
Pregnancy/breastfeeding, active skin infection, autoimmune flare, known hypersensitivity

PN-HPT: What Makes Plinest Different

Polynucleotides are purified fragments of DNA that act as regenerative signalling molecules. What distinguishes different polynucleotide products is the source tissue, the purification process, and the resulting fragment length and purity. Plinest uses Mastelli’s PN-HPT (Polynucleotides Highly Purified Technology) process, which produces high-molecular-weight polynucleotide chains with a very high purity profile.

In practice, PN-HPT produces long-chain polynucleotides that are retained in the tissue for longer, supporting sustained fibroblast activation. This is one of the reasons Plinest has a particularly strong evidence base in regenerative dermatology and has been in clinical use longer than most current polynucleotide products. Plinest is CE-marked for use in the UK and EU.

Like all polynucleotide products used in UK aesthetics, Plinest is derived from a fish source (salmon trout) chosen because its DNA has a structure highly compatible with human tissue and produces a negligible immune response. The purification process removes all cellular material; only the purified nucleotide chains remain.

What Plinest Does in the Skin

Once injected, Plinest polynucleotides act through several complementary mechanisms:

  • Fibroblast activation. Polynucleotides stimulate fibroblasts to produce collagen, elastin and extracellular matrix, supporting structural skin quality.
  • Hydration. Polynucleotides have a strong hydrating effect at the tissue level, improving plumpness and radiance.
  • Antioxidant activity. Polynucleotides scavenge free radicals, reducing oxidative stress that drives ageing.
  • Microcirculation. Local blood flow and nutrient delivery to the skin improve, supporting cellular repair.
  • Anti-inflammatory signalling. Polynucleotides reduce inflammatory signalling that otherwise accelerates skin ageing.

The combined effect is a visible and measurable improvement in skin quality: smoother texture, better hydration, improved elasticity, reduced fine lines and a healthier radiance. Plinest does not add volume and does not restrict muscle movement; it is a skin-quality treatment.

What Plinest Treats

Under-eye area

Plinest is widely used in the under-eye area, where the thin, fragile skin responds well to regenerative signalling. It can reduce crepiness, fine lines and the appearance of dark circles caused by skin transparency. It is often chosen for patients who want to avoid filler in the tear-trough or as a complementary treatment alongside carefully placed tear-trough filler.

Full-face skin quality

A full-face Plinest course improves overall skin quality: smoother texture, better hydration, radiance, and reduced fine lines. It is particularly effective in patients with dehydrated, sun-damaged or dull skin and those who want a natural improvement without volumising.

Neck and décolletage

The neck and décolletage respond well to polynucleotide therapy. Plinest can improve crepey skin, horizontal lines and overall skin quality in these areas, which are often under-treated and difficult to improve with other injectables.

Post-acne texture

Plinest supports the skin’s recovery from post-acne textural change. It is often combined with energy-based treatments such as Morpheus8 or microneedling for a stronger result.

Plinest vs Ameela vs Profhilo

Plinest vs Ameela

Both are polynucleotide injectables with the same mechanism of action. Plinest uses Mastelli’s PN-HPT technology to produce longer-chain polynucleotides; Ameela (Vivacy) has a slightly different molecular profile. Clinical outcomes are very similar. The choice between them is usually technical: which formulation fits the area and the chosen technique best. See our Ameela vs Plinest comparison for detail.

Plinest vs Profhilo

Profhilo is a hyaluronic acid bio-remodeller that delivers very high concentrations of HA for hydration and subtle lifting, with some secondary collagen and elastin stimulation. Plinest (polynucleotide) works more directly on fibroblast regeneration and tissue repair. Profhilo often produces a more immediate radiance and mild lifting effect; Plinest is often stronger for thin skin, crepiness, post-inflammatory texture and under-eye concerns. The two are complementary and many patients benefit from both in a staged plan.

Plinest vs dermal fillers

Fillers add immediate volume and reshape contours; Plinest improves skin quality. These are different treatments with different goals. Plinest does not replace a well-placed filler when volume restoration is the aim.

What a Treatment Course Involves

A typical Plinest course is 2–3 sessions spaced 3–4 weeks apart. Each session takes 20–30 minutes. After topical anaesthetic, the product is injected using a fine needle or cannula depending on the area. Small bumps at injection points typically settle within 24 hours. Mild bruising and tenderness are possible.

Aftercare is simple: avoid make-up for 12 hours, vigorous exercise for 24 hours, saunas and alcohol for 48 hours. Most patients return to work the same day.

Improvement builds over 4–8 weeks after each session. A review at 2–3 months after the final session assesses the result and plans maintenance, which is typically one session every 6–9 months.

Plinest FAQs

What is Plinest?
Plinest is a polynucleotide injectable manufactured by Mastelli in Italy. It uses the company's patented PN-HPT (Polynucleotides Highly Purified Technology) to produce long-chain polynucleotide fragments that stimulate fibroblast activity, improve hydration and support tissue regeneration. Plinest is one of the original polynucleotide products and has the longest clinical track record among current UK polynucleotides.
How does Plinest differ from Ameela?
Plinest (Mastelli) and Ameela (Vivacy) are both polynucleotide injectables with the same mechanism of action and very similar clinical outcomes. Plinest uses PN-HPT technology to produce longer-chain polynucleotides and has a slightly different viscosity profile. The practical choice between them is usually made by the treating clinician based on the indication, the injection technique and which formulation best fits the treatment area. Many clinics use both products for different purposes.
What is the Plinest "family" of products?
Mastelli produces several polynucleotide products under the Plinest and Newest brand names, formulated for different indications — including facial skin quality, delicate areas such as the under-eye, and scalp protocols. At Berkshire Aesthetics we carry the Plinest products that are most relevant to the indications we treat; the exact product used is selected based on your assessment.
What does Plinest treat?
Plinest is used for skin regeneration and quality improvement: fine lines, dehydrated skin, under-eye crepiness, post-acne textural change, early skin laxity and overall radiance. It is frequently used on the face, neck and décolletage. It does not add volume and does not replace dermal fillers where volume restoration is needed.
How many Plinest sessions do I need?
A typical Plinest course is 2–3 sessions spaced 3–4 weeks apart. Patients with more advanced concerns may have 4 sessions. Maintenance is usually one session every 6–9 months to sustain the outcome.
How long do Plinest results last?
Results build over 4–8 weeks after each session, with peak benefit at 2–3 months after the final session. Improvements last 6–9 months. Because polynucleotides work by stimulating the skin's own regenerative machinery, the benefit continues beyond the physical presence of the product.
Does Plinest hurt?
Topical anaesthetic is applied before injection. Most patients describe a brief pinch with some pressure. Small bumps and mild bruising at injection points are common and settle within 24–48 hours.
Is Plinest safe in pregnancy?
No. Plinest is not recommended during pregnancy or breastfeeding. It is also not suitable for patients with active skin infection at the treatment site, autoimmune flare, or known hypersensitivity to any component. Suitability is assessed at consultation.
How much does Plinest cost?
At Berkshire Aesthetics, Plinest is priced from £425 per session. A typical course of 2–3 sessions ranges from £850 to £1,275 depending on how many areas are treated. Pricing is confirmed at consultation.
Can Plinest be combined with other treatments?
Yes. Plinest is routinely combined with Profhilo (for hydration), dermal fillers (for volume), anti-wrinkle injections (for dynamic lines), and energy-based treatments such as Morpheus8 as part of a broader plan. Sequencing matters — Plinest is usually delivered as its own course and then layered with other treatments. Your clinician will plan the order.

Doctor-led approach

  • Treatment suitability is assessed by our doctors or advanced aesthetic practitioners during a clinical consultation, depending on the treatment
  • Prescribing responsibility sits with Dr Selena Langdon (GMC 6159259)
  • No same-day injectable treatments for new patients
  • Read our full Consultation & Safety Standards

Why we start with a consultation

Every treatment begins with a medical assessment. We need to understand your medical history, current health, skin condition and concerns before prescribing any procedure. This protects your safety and ensures the treatment is clinically appropriate for you.

During your consultation, your clinician will explain what the treatment can realistically achieve, any risks specific to you, and whether an alternative might be more appropriate. Consultations are carried out by our doctors or advanced aesthetic practitioners, depending on the treatment or concern being assessed.

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This content is for informational purposes only and does not constitute medical advice. Individual suitability for any treatment is assessed during a consultation. Always seek the guidance of a qualified medical professional with any questions regarding a medical condition or treatment.

Clinical governance

Page last reviewed: April 2026

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