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Profhilo vs Polynucleotides
Comparing bio-remodelling with tissue regeneration for skin quality
Book ConsultationProfhilo and polynucleotides are both injectable skin quality treatments, but they work through different biological mechanisms. Profhilo uses ultra-pure hyaluronic acid to bio-remodel the skin from within, while polynucleotides harness DNA fragments to stimulate tissue repair and regeneration. Understanding these differences will help you choose the right treatment for your skin concerns.
Bio-remodelling with ultra-pure HA
Best For
- • Skin laxity
- • Firmness
- • Crepey skin
- • Neck/décolletage
- • Hands
Not Suitable For
- • Under-eye area
- • Scarring
- • Very localised concerns
Duration
6-12 months
Results Visible
4-8 weeks
Starting Price
From £300 per session
Downtime
Minimal — small bumps 24-48 hours
DNA fragments stimulating tissue repair
Best For
- • Under-eye rejuvenation
- • Scarring
- • Skin regeneration
- • Sensitive areas
- • Fine lines
Not Suitable For
- • Skin tightening
- • Volume loss
- • Immediate results
Duration
6-12 months
Results Visible
4-6 weeks
Starting Price
From £250 per session
Downtime
Minimal — possible redness 24 hours
Frequently Asked Questions
What is the main difference?
The fundamental difference lies in their mechanisms. Profhilo uses high-concentration hyaluronic acid that spreads beneath the skin to stimulate collagen and elastin production, creating an overall bio-remodelling effect. Polynucleotides use DNA fragments derived from salmon or trout to activate fibroblasts and promote genuine tissue regeneration at a cellular level. Your practitioner will explain which mechanism best addresses your concerns during consultation.
Which is better for under-eye?
Polynucleotides are generally the preferred choice for under-eye rejuvenation. The delicate periorbital skin responds well to the regenerative properties of polynucleotides, which can improve dark circles, crepiness, and fine lines in this area. Profhilo is not typically recommended for the under-eye area due to the way hyaluronic acid behaves in very thin skin. Suitability will be assessed during your consultation.
Can they be combined?
Yes, Profhilo and polynucleotides can work very well together as they target different aspects of skin quality. For example, Profhilo can be used for overall facial and neck bio-remodelling while polynucleotides address specific areas such as the under-eye or areas of scarring. Dr Langdon can design a combined treatment plan tailored to your needs during consultation.
Which works faster?
Both treatments require time for the biological processes to take effect. Polynucleotides may show initial improvements slightly earlier at around four to six weeks, while Profhilo typically reaches its full effect at six to eight weeks after the second session. Neither treatment provides instant visible results, as both rely on stimulating the skin's own regenerative processes. Expected timelines will be discussed during your consultation.
Which is better for ageing skin?
Both treatments are excellent for ageing skin but address different aspects. Profhilo is particularly effective for overall skin laxity, firmness, and hydration across larger areas such as the face, neck, and hands. Polynucleotides excel at cellular-level regeneration and are particularly useful for delicate areas and scarring. For comprehensive anti-ageing, combining both treatments may provide the best outcome, which can be discussed during consultation.
Still Not Sure Which Treatment Is Right for You?
Book a consultation with Dr Langdon to discuss your concerns. She'll assess your skin and recommend the most suitable treatment plan.
Book Your ConsultationWhich is right for you?
The best treatment depends on your individual concerns, skin type, and goals. Here are some general considerations:
- Choose Profhilo if your main concern is overall skin laxity, loss of firmness, or crepey skin across the face, neck, or hands
- Choose polynucleotides if you want to target specific areas such as the under-eye, improve scarring, or regenerate delicate skin
- Consider combining both if you want comprehensive skin quality improvement addressing both bio-remodelling and cellular regeneration
- If you are unsure, a consultation will help clarify which approach addresses your specific concerns
This is general guidance only — treatment suitability is always confirmed during a clinical consultation.
Doctor-led approach
- Treatment suitability is assessed by a doctor during a clinical consultation
- Prescribing responsibility sits with Dr Selena Langdon (GMC 6159259)
- No same-day injectable treatments for new patients
- Read our full Consultation & Safety Standards
- CQC registered clinic — regulated and inspected
- Doctor-led clinical oversight by Dr Selena Langdon (GMC 6159259)
- Complaints process and patient rights
Reviewed by Dr Selena Langdon, Medical Director (GMC 6159259) — Last reviewed: February 2026
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