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Plinest vs Profhilo
Two injectable skin-quality treatments — tissue regeneration vs bio-remodelling
Book ConsultationPlinest and Profhilo are both injectable skin-quality treatments, but they work through fundamentally different mechanisms. Plinest delivers purified polynucleotides (PN-HPT, derived from salmon DNA) that stimulate fibroblasts and promote genuine tissue regeneration at a cellular level. Profhilo uses stabilised hyaluronic acid (HA) to bio-remodel the skin through intense hydration and stimulation of collagen and elastin. Understanding the differences — and where each treatment is genuinely the better choice — helps ensure you receive the most appropriate care for your concerns.
Polynucleotides (PN-HPT, salmon DNA) for cellular regeneration
Best For
- • Under-eye rejuvenation (the periorbital area is a particular strength)
- • Skin regeneration and quality at a cellular level
- • Crepey skin, fine lines and dehydration
- • Post-acne textural change and early skin laxity
- • Patients seeking a regenerative, biostimulatory approach
Not Suitable For
- • Patients expecting immediate, single-session results
- • Volume restoration or facial contouring
- • Active skin infection or inflammation at the treatment site
- • Pregnancy or breastfeeding
- • Known hypersensitivity to fish-derived products
Results Visible
Gradual — 4–8 weeks per session, peak at 2–3 months after the final session
Sessions
2–3 sessions, 3–4 weeks apart
Starting Price
From £425 per session
Downtime
Minimal — small bumps and mild bruising for 24–48 hours
Stabilised hyaluronic acid for bio-remodelling and hydration
Best For
- • Skin laxity, firmness and elasticity across the face and neck
- • Crepey skin on the décolletage and hands
- • Hydration and overall skin glow
- • Fine lines linked to dehydration
- • Patients wanting visible improvement after a short, two-session protocol
Not Suitable For
- • The under-eye area — Profhilo is not typically used periorbitally
- • Very localised concerns or single-area scarring
- • Volume restoration or contouring
- • Significant skin laxity where lifting is the primary goal
- • Active skin conditions in the treatment area
Results Visible
2–4 weeks after the second session
Sessions
2 sessions, 4 weeks apart
Starting Price
From £350 per session
Downtime
Minimal — small bumps at injection sites settle within 24–48 hours
Which is right for you?
Choose Plinest if
- • Your main concern is the under-eye area — periorbital rejuvenation is one of its clearest strengths
- • You want cellular-level regeneration rather than HA-based hydration
- • You have post-acne textural change or early skin laxity to address
- • You are comfortable with a 2–3 session course over several weeks
Choose Profhilo if
- • Your concern is overall facial skin laxity, firmness or crepey neck/décolletage skin
- • Hydration and skin glow are your primary goals
- • You prefer a shorter, two-session protocol with visible results within weeks
- • You want to treat larger areas (face plus neck, or hands) in a single course
Consider combining both when
- • You want overall bio-remodelling for the face and neck (Profhilo) plus targeted under-eye regeneration (Plinest)
- • Your doctor recommends a staged plan addressing different layers and concerns
- • You want comprehensive skin-quality improvement across multiple areas
This is general guidance only — treatment suitability is always confirmed during a clinical consultation.
Frequently Asked Questions
What is the main difference between Plinest and Profhilo?
Plinest uses polynucleotides — purified DNA fragments from salmon — that stimulate fibroblasts and promote tissue regeneration at a cellular level. Profhilo uses stabilised hyaluronic acid that spreads beneath the skin to attract water and stimulate collagen and elastin production, producing a bio-remodelling effect. They are both injectable skin-quality treatments, but the mechanism, ideal treatment areas and clinical use cases differ. Your doctor will explain which is more appropriate for your specific concerns at consultation.
Which is better for under-eyes?
Plinest is generally the preferred choice for the under-eye area. The delicate periorbital skin responds well to the regenerative properties of polynucleotides, which can improve crepiness, fine lines and skin quality in this area. Profhilo is not typically used periorbitally because of how hyaluronic acid behaves in very thin skin. Suitability for the under-eye area is always assessed clinically during consultation.
Can Plinest and Profhilo be combined?
Yes — they target different aspects of skin quality and can complement each other. A common combined plan uses Profhilo across the face, neck or décolletage for overall bio-remodelling, with Plinest used in the under-eye area for targeted regeneration. Combined treatment plans are designed at consultation based on your clinical assessment, concerns and goals.
Which works faster — Plinest or Profhilo?
Profhilo typically produces visible improvement slightly faster, with results visible 2–4 weeks after the second session of a two-session course. Plinest is more gradual: improvements build across each session, with peak benefit usually seen 2–3 months after the final session of a 2–3 session course. Neither treatment provides instant change — both rely on stimulating the skin’s own regenerative processes. Expected timelines will be discussed during your consultation.
How long do the results last?
Profhilo results typically last around six months, with maintenance recommended every 6–12 months depending on individual response. Plinest results commonly last 6–9 months, with maintenance usually one session every 6–9 months. Longevity varies by individual, age, skin condition and lifestyle factors — this is discussed during consultation as part of your treatment plan.
Are Plinest and Profhilo safe?
Both treatments have well-established safety profiles when delivered by appropriately trained doctors. Common side effects include mild swelling, redness or small bumps at injection sites, typically settling within 24–48 hours. Plinest is contraindicated in pregnancy, breastfeeding, active skin infection at the treatment site, and in patients with known hypersensitivity to fish-derived products. Profhilo is contraindicated in pregnancy, breastfeeding and active skin conditions in the treatment area. Suitability is always confirmed at clinical consultation.
How much do Plinest and Profhilo cost in Maidenhead?
At Berkshire Aesthetics, Plinest is priced from £425 per session, with a typical course of 2–3 sessions. Profhilo is priced from £350 per session, with a course of two sessions four weeks apart. Final pricing is confirmed at consultation based on the areas treated and your treatment plan.
Still Not Sure Which Treatment Is Right for You?
Book a consultation with one of our GMC-registered doctors at our CQC-registered clinic in Maidenhead. Your doctor will assess your skin and recommend the most suitable treatment plan.
Book Your ConsultationDoctor-led approach
- Treatment suitability is assessed by our doctors or advanced aesthetic practitioners during a clinical consultation, depending on the treatment
- Prescribing responsibility sits with Dr Selena Langdon (GMC 6159259)
- No same-day injectable treatments for new patients
- Read our full Consultation & Safety Standards
- CQC registered clinic — regulated and inspected
- Doctor-led clinical oversight by Dr Selena Langdon (GMC 6159259)
- Complaints process and patient rights
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