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Julaine vs Profhilo
Two approaches to skin rejuvenation — collagen stimulation vs bio-remodelling
Book ConsultationJulaine and Profhilo are both injectable skin-quality treatments, but they work through fundamentally different mechanisms. Julaine (JULÄINE) is a PLLA collagen biostimulator that triggers your body to produce new collagen over months. Profhilo uses stabilised hyaluronic acid to bio-remodel the skin through intense hydration and stimulation of collagen and elastin. Understanding these differences helps determine which treatment — or combination — will best address your skin concerns.
PLLA collagen biostimulator for gradual collagen production
Best For
- • Progressive improvement in skin firmness and texture
- • Patients who want long-lasting collagen stimulation
- • Skin laxity on face and neck
- • Those comfortable with gradual results over 3-6 months
- • Patients seeking a natural rejuvenation approach
Not Suitable For
- • Immediate visible change (results are gradual)
- • Those wanting hydration as the primary goal
- • Patients with active skin infection or inflammation
- • Anyone seeking volume restoration
Results Timeline
3-6 months (progressive)
Sessions
2-3 sessions, 4-6 weeks apart
Starting Price
From £750
Downtime
Minimal — mild swelling/redness 24-48 hours
Stabilised hyaluronic acid for bio-remodelling and intense hydration
Best For
- • Skin hydration and elasticity improvement
- • Fine lines and crepey skin
- • Face, neck, décolletage and hands
- • Those wanting visible improvement after 2 sessions
- • Patients seeking skin glow and smoothness
Not Suitable For
- • Volume restoration or contouring
- • Significant skin laxity (other options may be better)
- • Those seeking long-term collagen stimulation only
- • Active skin conditions in the treatment area
Results Timeline
2-4 weeks after second session
Sessions
2 sessions, 4 weeks apart
Starting Price
From £350
Downtime
Minimal — small bumps at injection sites resolve quickly
When We Recommend Each Treatment
Choose Julaine if
- Your main concern is skin firmness and long-term quality
- You want results that continue to improve for months
- You prefer fewer maintenance sessions (results last longer)
- You want collagen stimulation rather than hydration
Choose Profhilo if
- Your skin is dehydrated, dull or lacks elasticity
- You want visible results within a few weeks
- You prefer a 2-session protocol
- Hydration and skin glow are your primary goals
Consider combining both when
- You want both deep collagen stimulation and surface hydration
- Dr Langdon recommends a staged approach for your skin goals
- You want comprehensive skin rejuvenation across multiple layers
Frequently Asked Questions
Can I have both Julaine and Profhilo?
Yes. Many patients benefit from combining both — Profhilo for immediate hydration and bio-remodelling, followed by Julaine for longer-term collagen stimulation. Your clinician will advise on timing and sequence during consultation.
Which lasts longer?
Julaine typically produces longer-lasting results as it stimulates your own collagen production, with effects that can last 12-24 months. Profhilo results typically last 6-9 months before a maintenance session is needed.
Which is better for the neck?
Both can treat the neck effectively. Profhilo is excellent for neck hydration and fine lines. Julaine addresses deeper firmness concerns. The best choice depends on whether your main concern is texture/hydration or laxity/firmness.
Are these treatments painful?
Both involve injections and may cause mild discomfort. Profhilo uses 5 injection points per side of the face (BAP technique). Julaine involves multiple small injections. Neither typically requires anaesthetic.
How do I know which is right for me?
This is assessed during your consultation. Your clinician will evaluate your skin quality, hydration levels, degree of laxity, and your goals to recommend the most appropriate treatment or combination.
Not Sure Which Skin Treatment Is Right?
Book a consultation to discuss your skin concerns and goals. We will recommend the most effective approach for your skin.
Book Your ConsultationWhich is right for you?
The best treatment depends on your individual concerns, skin type, and goals. Here are some general considerations:
- Choose Julaine if your primary goal is long-term collagen stimulation and skin firmness
- Choose Profhilo if you want hydration, glow and visible improvement within weeks
- Both treatments work well on the face, neck and other areas — the best choice depends on your specific skin concerns
- Some patients benefit from combining both treatments for comprehensive rejuvenation — discuss this during your consultation
This is general guidance only — treatment suitability is always confirmed during a clinical consultation.
Doctor-led approach
- Treatment suitability is assessed by our doctors or advanced aesthetic practitioners during a clinical consultation, depending on the treatment
- Prescribing responsibility sits with Dr Selena Langdon (GMC 6159259)
- No same-day injectable treatments for new patients
- Read our full Consultation & Safety Standards
- CQC registered clinic — regulated and inspected
- Doctor-led clinical oversight by Dr Selena Langdon (GMC 6159259)
- Complaints process and patient rights
Reviewed by Dr Selena Langdon, Medical Director (GMC 6159259) — Last reviewed: February 2026
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